

 
Communications Directorate 
Press and Information Unit curia.europa.eu 
 
 
 
PRESS RELEASE No 56/24 
Luxembourg, 21 March 2024 
Advocate General’s Opinion in Joined Cases C-611/22 P | Illumina v Commission and C-625/22 P Grail v 
Commission and Illumina 
Illumina-Grail Merger: AG Emiliou proposes to set aside the General Court 
judgment and annul Commission decisions on referral request 
He is of the view that Member States may not request the Commission to examine a concentration which does 
not have a Community dimension where they have no competence to review such a concentration under 
national law 
The EU system of merger control – governed by the Merger Regulation 
1
 – is primarily based on the turnover of the 
merging companies. Some provisions in that regulation, particularly Article 22, by way of exception empower the 
Commission to review mergers not meeting the turnover thresholds in question, when cases are referred to it by 
the Member States’ authorities and, as the case may be, after being invited to do so by the Commission. 
In the present case the Court of Justice is essentially required to assess whether Article 22 of the Merger Regulation 
enables the Commission to review a merger referred to it by some Member State’s authorities, where the latter lack 
any competence to review it, since the merger in question falls below the thresholds set out in their national 
legislation on merger control. 
The merger involves the acquisition of sole control of Grail LLC, a US-based company that develops blood tests for 
the early detection of cancer, by Illumina Inc. – another US-based company marketing sequencing- and array-based 
solutions for genetic and genomic analysis. Since the merger did not have a European dimension, due to the low 
turnover of the parties as defined by the Merger Regulation, it was not notified to the Commission. Additionally, 
since it did not fall within the scope of national merger control rules, it was also not notified to EU and EEA Member 
States. 
Following a complaint relating to the concentration and having invited the Member States to submit a referral 
request, the Commission received such a request from the French Competition Authority asking it to examine the 
concentration at issue 
2
. Through an information letter, the Commission informed Illumina and Grail of the referral 
request, stating that the concentration at issue could not be implemented provided that, and in so far as, the 
standstill obligation laid down in the Merger Regulation was applicable. By its judgment in Illumina v Commission 
3
, 
the General Court dismissed the action by Illumina challenging that information letter and the Commission’s 
decisions accepting the referral and the requests to join it. Illumina and Grail have appealed this judgment. 
In today’s Opinion, Advocate General Nicholas Emiliou proposes that the Court should set aside the General 
Court judgment and annul the Commission decisions accepting the referral and the requests to join it as 
well as the Commission’s information letter.  
Advocate General Emiliou finds that the General Court erred in its interpretation of Article 22 of the Merger 
Regulation when it came to the conclusion that a ‘literal, historical, contextual and teleological’ interpretation of 
that provision supported the view that Member States may request the Commission to examine a 

 
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concentration which does not have a Community dimension, even where they have no competence to 
review such a concentration under national law.   
After considering the wording, origin, context and purpose of that provision, and having taken into account the logic 
of the EU system of merger control as well as of some fundamental principles of EU law (such as institutional 
balance, subsidiarity, legal certainty, and territoriality), the Advocate General takes the view that Article 22 of the 
Merger Regulation cannot be interpreted as supporting the General Court’s broad interpretation of the provision.  
Such interpretation gives rise, inter alia, to a very significant extension of the scope of the Merger Regulation and of 
the Commission’s jurisdiction. In one fell swoop, the Commission would gain the power to review almost any 
concentration, occurring anywhere in the world, regardless of undertakings’ turnover and presence in the European 
Union and the value of the transaction, and at any moment in time, including well after the completion of the 
merger. Moreover, the procedures that would result from a broad interpretation of Article 22 of the Merger 
Regulation would hardly be efficient, predictable and capable of ensuring legal certainty to the parties. 
AG Emiliou concludes that the General Court erred in its interpretation and application of Article 22 of the 
Merger Regulation. Under a proper construction, that provision does not empower the Commission to adopt 
decisions such as those challenged, and therefore those decisions and the information letter should be 
annulled. 
NOTE: The Advocate General’s Opinion is not binding on the Court of Justice. It is the role of the Advocates General 
to propose to the Court, in complete independence, a legal solution to the cases for which they are responsible. The 
Judges of the Court are now beginning their deliberations in this case. Judgment will be given at a later date. 
NOTE: An appeal, on a point or points of law only, may be brought before the Court of Justice against a judgment or 
order of the General Court. In principle, the appeal does not have suspensive effect. If the appeal is admissible and 
well founded, the Court of Justice sets aside the judgment of the General Court. Where the state of the proceedings 
so permits, the Court of Justice may itself give final judgment in the case. Otherwise, it refers the case back to the 
General Court, which is bound by the decision given by the Court of Justice on the appeal. 
Unofficial document for media use, not binding on the Court of Justice. 
The full text of the Opinion is published on the CURIA website on the day of delivery.  
Press contact: Jacques René Zammit ✆  (+352) 4303 3355. 
Pictures of the delivery of the Opinion are available from “Europe by Satellite" ✆  (+32) 2 2964106. 
 
 
 
 
1
 Council Regulation (EC) No 139/2004 of 20 January 2004 on the control of concentrations between undertakings (the EC Merger Regulation) 
2
 The referral request was made by the French Competition Authority while the Belgian, Greek, Icelandic, Netherlands and Norwegian authorities 
asked to join the referral. 
3
 Judgment of 13 July 2022, Illumina v Commission, T-227/21, (see Press release N
o
 123/22). 

Advocate General's Opinion on Illumina-Grail Merger

The Advocate General's opinion in the Illumina-Grail merger case challenges the General Court's interpretation of Article 22 of the Merger Regulation. The case questions whether the Commission can review a merger referred by Member States lacking the competence to review it under national law. The merger involves Illumina Inc. acquiring sole control of Grail LLC, a US-based company developing cancer detection tests. The Advocate General argues that a broad interpretation of Article 22 would extend the Commission's jurisdiction significantly, leading to inefficiencies and legal uncertainties for parties involved. The Advocate General recommends annulling the Commission's decisions and the information letter. The Court of Justice will deliberate on the case, with the judgment to be delivered later.

Advocate General's Opinion on Illumina-Grail Merger

Advocate General Emiliou proposes to set aside the General Court judgment and annul Commission decisions on referral request regarding the Illumina-Grail merger.